The Italian keeper started in the youth ranks with Atalanta before moving to Arsenal in 2005.
He impressed in the Gunners' youth ranks but made his professional debut on loan at Barnsley in August 2006.
Mannone made his Arsenal bow on the final day of the 2008/09 season against Stoke City, in a 4-1 victory, and went on to make a total of 23 appearances for the club - 15 of them coming in the Premier League.
The former Italy under-21 keeper enjoyed two loan spells with Hull City before joining Sunderland on a permanent deal in the summer of 2013.
He ended his first season as the club's Player of the Year and supporters' Player of the Year, having helped the Black Cats reach the League Cup final against Manchester City.
Mannone played a key role in keeping Sunderland in the Premier League in 2015/16 and was rewarded with a new two-year contract.
He left the club following their relegation to the Championship in 2017, joining Reading, where he has established himself as first-choice keeper under Jaap Stam.